Maitotoxin; Okadaic acid and dinophysistoxins; Palytoxins and ostreocins; Pectenotoxins; Polycavernosides; and Yessotoxins. In addition, several mechanistic
Okadaic acid is a toxin that is known for causing diarrhetic shellfish poisoning. It selectively inhibits phosphatases, so it is often used as a research chemical to study phosphorylation. As it turns out, in the brain it hyperphosphorylates tau, which causes it to tangle.
This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 Okadaic Acid mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC. Summary: PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes.
If you accept without changing your settings, we assume that you are happy to receive all cookies on the LGC website. Okadaic acid also activated NGF gene transcription, which was preceded by an induction of c-fos and c-jun gene transcription. The induction of NGF expression by okadaic acid appeared independent from protein kinase C activity because down-regulating protein kinase C activity failed to decrease the okadaic acid … OKADAIC ACID : Molecular formula: C 44 H 68 O 13: Description: It is a potent protein phosphatase 1A and 2A inhibitor. Polyether derivative of C-38 fatty acid , from the microorganism Prorocentrum lima: Biological activity: It is a very potent inhibitor of protein phosphatases-1 (PP1) and -2A (PP2A) that also stimulates the phosphorylation of Okadaic acid significantly increased phosphorylation of CaMKII; indicating a major role of PP1 in CaMKII dephosphorylation. Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Okadaic Acid, Free Acid, >98%, CAS#78111-17-8, More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels).
Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = 0.1 nM).
Keywords: Okadaic Acid, Diarrhetic Shellfish, protein kinases (PKs), threonine-specific (PSPs), tyrosine-specific (PTPs) enzymes, OKADAIC ACID CLASS INHIBITORS, Halichondria okadai, Pandoras acanthifolium, Dinophysis, Prorocentrum
Apoptosis Inducer & Phosphatase Inhibitor; induces apoptosis e.g. in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells.
Visit ChemicalBook To find more OKADAIC ACID(78111-17-8) information like chemical properties,Structure,melting point,boiling point,density,molecular
Okadaic acid blocks LLC-PK cells in mitosis LLC-PK cells were treated with various concentrations of okadaic acid (OA) to determine its effect on cell growth. OA was added to the culture media 24 h after cells had been subcultured, and monolayers were maintained for an additional 24-48 h, at which time the number of cells remaining in the ChEBI Name okadaic acid: ChEBI ID CHEBI:44658: Definition A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. Lipid metabolism in visceral fat cells is correlated with metabolic syndrome and cardiovascular diseases. Okadaic-acid, a 38-carbon fatty acid isolated from the black sponge Halichondria okadai, can stimulate lipolysis by promoting the phosphorylation of several proteins in adipocytes. Okadaic Acid: Equivalent Term Ocadaic Acid: CAS Registry Number 78111-17-8 Definition : A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter.
Okadaic Acid is an activator of PKC.
Summary: PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes.
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Okadaic Acid, Free Acid, >98%, CAS#78111-17-8, More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels). Okadaic Acid: Equivalent Term Ocadaic Acid: CAS Registry Number 78111-17-8 Definition : A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter.
OA was named from the marine sponge Halichondria okadai, from which OA was isolated for the first time. It has also been isolated from another marine sponge, H. malanodocia, as a cytotoxin.
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Okadaic acid is a polyether derivative of 38-carbon fatty acid, and is implicated as the causative agent of diarrhetic shellfish poisoning. It is a potent tumour promoter that is not an activator of protein kinase C, but is a powerful inhibitor of protein phosphatases-1 and -2A (PP1 and PP2A) in vitro.
In this work the absorption of okadaic acid by those cells has been studied by supplying the toxin dissolved in water and including it in oil droplets given to primary cell cultures, and by checking if the uptake is Okadaic acid blocks LLC-PK cells in mitosis LLC-PK cells were treated with various concentrations of okadaic acid (OA) to determine its effect on cell growth. OA was added to the culture media 24 h after cells had been subcultured, and monolayers were maintained for an additional 24-48 h, at which time the number of cells remaining in the Okadaic Acid (sodium salt) solution in methanol reference standards available online at LGC Standards, for food and beverage analysis. We use cookies to ensure that we give you the best experience of our website. If you accept without changing your settings, we assume that you are happy to receive all cookies on the LGC website.
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Okadaic acid also activated NGF gene transcription, which was preceded by an induction of c-fos and c-jun gene transcription. The induction of NGF expression by okadaic acid appeared independent from protein kinase C activity because down-regulating protein kinase C activity failed to decrease the okadaic acid …
It is also a potent tumor promoter. It is produced by DINOFLAGELLATES and causes diarrhetic SHELLFISH POISONING. Structure : Top Interacting Genes Okadaic Acid, Free Acid, >98%, CAS#78111-17-8, More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels). This work describes the selection and identification of DNA aptamers that bind with high affinity and specificity to okadaic acid (OA), a lipophilic marine biotoxin that accumulates in shellfish. The aptamers selected using systematic evolution of ligands by exponential enrichment (SELEX) exhibited dissociation constants in the nanomolar range. The aptamer with the highest affinity was then Okadaic acid, C 44 H 68 O 13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. One of the primary causes of diarrhetic shellfish poisoning , okadaic acid is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.